In Autumn 2011, the Government Council of the Canton of Zurich decided on the siting for the new UniversityHospital: the new hospital will not be built on the green field site, but continue to be developed in the centre of Zurich. The conference organisers gave an overview of the current status of work on this once-in-a-century project. Also invited were speakers who put up for discussion various aspects and considerations concerning further development of the UniversityHospital Zurich from an external viewpoint. Professor Hans Nickl examined the project’s construction challenges in his talk.